With the discovery of induced pluripotent stem (iPS) cells, it is now possible to convert
differentiated somatic cells into multipotent stem cells that have the capacity to generate all …

This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

A large number of drugs can induce prolongation of cardiac repolarization and life-
threatening cardiac arrhythmias. The prediction of this side effect is however challenging as …

Induced pluripotent stem cells (iPSCs) are terminally differentiated somatic cells that
differentiate into various cell types. iPSCs are expected to be used for disease modeling and …

Technical advances in generating and phenoty** cardiomyocytes from human pluripotent
stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to …

Drug-induced cardiotoxicity is a significant clinical issue, with many drugs in the market
being labeled with warnings on cardiovascular adverse effects. Treatments are often …

Rare diseases, in totality, affect a significant proportion of the population and represent an
unmet medical need facing the scientific community. However, the treatment of individuals …

Background Commercial genetic testing for long QT syndrome (LQTS) has rapidly
expanded, but the inability to accurately predict whether a rare variant is pathogenic has …

In the last decade, there has been tremendous progress in identifying genetic anomalies
linked to clinical disease. New experimental platforms have connected genetic variants to …

Induced pluripotent stem cells (iPSC) are important tools for drug discovery assays and
toxicology screens. In this manuscript, we design high efficiency TALEN and ZFN to target …