Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

The endocannabinoids are a family of lipid messengers that engage the cell surface
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

The primary psychoactive ingredient in cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), affects
the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in …

The medicinal use of Cannabis sativa L. can be traced back thousands of years to ancient
China and Egypt. While marijuana has recently shown promise in managing chronic pain …

Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …

Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2, both
coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and …

Migraine is a common and complex brain disorder. Although it is clear that head pain is a
key manifestation of the disorder for most patients, what drives the activation of neuronal …

Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid
mechanisms. Here we show that an opioid-independent form of this phenomenon, termed …

Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the
development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In …