To PEGylate or not to PEGylate: Immunological properties of nanomedicine's most popular component, polyethylene glycol and its alternatives

D Shi, D Beasock, A Fessler, J Szebeni… - Advanced drug delivery …, 2022 - Elsevier
Polyethylene glycol or PEG has a long history of use in medicine. Many conventional
formulations utilize PEG as either an active ingredient or an excipient. PEG found its use in …

The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Poly (ethylene glycol) alternatives in biomedical applications

X Yao, C Qi, C Sun, F Huo, X Jiang - Nano Today, 2023 - Elsevier
Abstract Poly (ethylene glycol)(PEG) as gold standard has been extensively conjugated to
diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is …

Poly (2-oxazoline) s based biomaterials: A comprehensive and critical update

T Lorson, MM Luebtow, E Wegener, MS Haider… - Biomaterials, 2018 - Elsevier
Abstract Poly (2-oxazoline) s have been investigated for decades as biomaterials.
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …

Surface functionalization of graphene‐based materials: Biological behavior, toxicology, and safe‐by‐design aspects

Z Guo, S Chakraborty, FA Monikh, DD Varsou… - Advanced …, 2021 - Wiley Online Library
The increasing exploitation of graphene‐based materials (GBMs) is driven by their unique
properties and structures, which ignite the imagination of scientists and engineers. At the …

Graphene oxide loaded with tumor-targeted peptide and anti-cancer drugs for cancer target therapy

R Li, Y Wang, J Du, X Wang, A Duan, R Gao, J Liu… - Scientific reports, 2021 - nature.com
In the present work, we constructed nanoscale graphene oxide (NGO) as a drug nanocarrier
to improve the process of tumor-targeted drug releases, promote cellular uptake and …

Drug Delivery Systems Based on Poly (2‐oxazoline) s and Poly (2‐oxazine) s

O Sedlacek, R Hoogenboom - Advanced Therapeutics, 2020 - Wiley Online Library
Abstract Poly (2‐oxazoline) s (PAOx) represent an established class of polymer materials
with a wide range of applications. In contrast, the homologous poly (2‐oxazine) s (PAOzi) …

Immunological Responses Induced by Blood Protein Coronas on Two-Dimensional MoS2 Nanosheets

D Baimanov, J Wu, R Chu, R Cai, B Wang, M Cao… - ACS …, 2020 - ACS Publications
Two-dimensional (2D) nanosheets (NSs) have a large surface area, high surface free
energy, and ultrathin structure, which enable them to more easily penetrate biological …

Bioinert, stealth or interactive: how surface chemistry of nanocarriers determines their fate in vivo

JD Friedl, V Nele, G De Rosa… - Advanced functional …, 2021 - Wiley Online Library
Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote
drug transport across membranes, to protect their payload from premature degradation, and …

Endocytosis and organelle targeting of nanomedicines in cancer therapy

X Wang, Y Qiu, M Wang, C Zhang, T Zhang… - International journal …, 2020 - Taylor & Francis
Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to
efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by …