Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Exercise is recognized by clinicians in the field of clinical oncology for its potential role in
reducing the risk of certain cancers and in reducing the risk of disease recurrence and …

Considerable evidence implicates cellular senescence in the biology of aging and chronic
disease. Diet and exercise are determinants of healthy aging; however, the extent to which …

Myostatin (Mstn) is predominantly expressed in skeletal muscles and plays important roles
in regulating muscle growth and development, as well as fat deposition. Mstn-knockout …

Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

Despite considerable efforts to develop efficient carriers, the major target organ of short-
interfering RNAs (siRNAs) remains limited to the liver. Expanding the application outside the …

Results: In HFD-fed mice, peptibody treatment stimulated muscle growth and improved
insulin resistance. The improved glucose and insulin tolerances were confirmed when we …

The progressive loss of skeletal muscle mass, strength and/or function with advancing age,
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …

Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological
and pathophysiological processes, including normal aging. There are no approved …

Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the life quality of elder people. In view of increasing life expectancy, sarcopenia …