Bioactive aurones, indanones, and other hemiindigoid scaffolds: medicinal chemistry and photopharmacology perspectives
LM Lazinski, G Royal, M Robin… - Journal of Medicinal …, 2022 - ACS Publications
Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …
Leishmania treatment and prevention: Natural and synthesized drugs
Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …
regions. Currently used antileishmanial synthesized drugs are associated with some …
3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
H Hadni, M Elhallaoui - Heliyon, 2020 - cell.com
The development of multi-resistant strains of plasmodium parasite has become a global
problem, therefore, the discovery of new antimalarial agents is the only available solution. In …
problem, therefore, the discovery of new antimalarial agents is the only available solution. In …
Aurone: A biologically attractive scaffold as anticancer agent
Aurones are very simple, promising anticancer lead molecules containing three rings (A, B
and C). A very slight structural variation in the aurones elicits diverse affinity and specificity …
and C). A very slight structural variation in the aurones elicits diverse affinity and specificity …
Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …
continues to reexamine and mine plant metabolites for novel compounds and to guide …
Chalcones: Versatile intermediates in heterocyclic synthesis
Chalcones are a fascinating and well‐studied group of organic molecules. Synthesis of
chalcones has been one of the essential areas of organic synthesis over the last few …
chalcones has been one of the essential areas of organic synthesis over the last few …
Exploring aurone derivatives as potential human pancreatic lipase inhibitors through molecular docking and molecular dynamics simulations
Inhibition of human pancreatic lipase, a crucial enzyme in dietary fat digestion and
absorption, is a potent therapeutic approach for obesity treatment. In this study, human …
absorption, is a potent therapeutic approach for obesity treatment. In this study, human …
L-proline-based natural deep eutectic solvents as efficient solvents and catalysts for the ultrasound-assisted synthesis of aurones via knoevenagel condensation
MA Karadendrou, I Kostopoulou, V Kakokefalou… - Catalysts, 2022 - mdpi.com
Aurones are minor flavonoids that possess a wide variety of bioactivity, including
antioxidant, anticancer, and enzyme inhibitory activity. L-proline-based natural deep eutectic …
antioxidant, anticancer, and enzyme inhibitory activity. L-proline-based natural deep eutectic …
Exploring the 2′-hydroxy-chalcone framework for the development of dual antioxidant and soybean lipoxygenase inhibitory agents
I Kostopoulou, A Tzani, NI Polyzos, MA Karadendrou… - Molecules, 2021 - mdpi.com
2′-hydroxy-chalcones are naturally occurring compounds with a wide array of bioactivity. In
an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) …
an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) …
Design, rational repurposing, synthesis, in vitro evaluation, homology modeling and in silico study of Sulfuretin Analogs as Potential Antileishmanial hit compounds
Direct growth inhibition of infectious organisms coupled with immunomodulation to
counteract the immunosuppressive environment might be a beneficial therapeutic approach …
counteract the immunosuppressive environment might be a beneficial therapeutic approach …