Bioactive aurones, indanones, and other hemiindigoid scaffolds: medicinal chemistry and photopharmacology perspectives

LM Lazinski, G Royal, M Robin… - Journal of Medicinal …, 2022 - ACS Publications
Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …

Leishmania treatment and prevention: Natural and synthesized drugs

AA Bekhit, E El-Agroudy, A Helmy, TM Ibrahim… - European journal of …, 2018 - Elsevier
Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …

3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents

H Hadni, M Elhallaoui - Heliyon, 2020 - cell.com
The development of multi-resistant strains of plasmodium parasite has become a global
problem, therefore, the discovery of new antimalarial agents is the only available solution. In …

Aurone: A biologically attractive scaffold as anticancer agent

A Alsayari, AB Muhsinah, MZ Hassan, MJ Ahsan… - European Journal of …, 2019 - Elsevier
Aurones are very simple, promising anticancer lead molecules containing three rings (A, B
and C). A very slight structural variation in the aurones elicits diverse affinity and specificity …

Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

A Parthasarathy, EJ Borrego, MA Savka… - Journal of Biological …, 2021 - ASBMB
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …

Chalcones: Versatile intermediates in heterocyclic synthesis

YN Nayak, SL Gaonkar, M Sabu - Journal of Heterocyclic …, 2023 - Wiley Online Library
Chalcones are a fascinating and well‐studied group of organic molecules. Synthesis of
chalcones has been one of the essential areas of organic synthesis over the last few …

Exploring aurone derivatives as potential human pancreatic lipase inhibitors through molecular docking and molecular dynamics simulations

PTV Nguyen, HA Huynh, DV Truong, TD Tran, CVT Vo - Molecules, 2020 - mdpi.com
Inhibition of human pancreatic lipase, a crucial enzyme in dietary fat digestion and
absorption, is a potent therapeutic approach for obesity treatment. In this study, human …

L-proline-based natural deep eutectic solvents as efficient solvents and catalysts for the ultrasound-assisted synthesis of aurones via knoevenagel condensation

MA Karadendrou, I Kostopoulou, V Kakokefalou… - Catalysts, 2022 - mdpi.com
Aurones are minor flavonoids that possess a wide variety of bioactivity, including
antioxidant, anticancer, and enzyme inhibitory activity. L-proline-based natural deep eutectic …

Exploring the 2′-hydroxy-chalcone framework for the development of dual antioxidant and soybean lipoxygenase inhibitory agents

I Kostopoulou, A Tzani, NI Polyzos, MA Karadendrou… - Molecules, 2021 - mdpi.com
2′-hydroxy-chalcones are naturally occurring compounds with a wide array of bioactivity. In
an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) …

Design, rational repurposing, synthesis, in vitro evaluation, homology modeling and in silico study of Sulfuretin Analogs as Potential Antileishmanial hit compounds

AHE Hassan, TN Phan, Y Choi, S Moon, JH No… - Pharmaceuticals, 2022 - mdpi.com
Direct growth inhibition of infectious organisms coupled with immunomodulation to
counteract the immunosuppressive environment might be a beneficial therapeutic approach …