The discovery of Asgard archaea, phylogenetically closer to eukaryotes than other archaea,
together with improved knowledge of microbial ecology, impose new constraints on …

Introns are ubiquitous in eukaryotic genomes and have long been considered as 'junk
RNA'but the huge energy expenditure in their transcription, removal, and degradation …

The emergence of eukaryotes from ancient prokaryotic lineages embodied a remarkable
increase in cellular complexity. While prokaryotes operate simple systems to connect DNA to …

Eukaryotic genes are characterized by the presence of introns that are removed from pre-
mRNA by a spliceosome. This ribonucleoprotein complex is comprised of multiple RNA …

RNA splicing is an essential step in producing mature messenger RNA (mRNA) and other
RNA species. Harnessing RNA splicing modifiers as a new pharmacological modality is …

Eukaryotes are typically depicted as descendants of archaea, but their genomes are
evolutionary chimeras with genes stemming from archaea and bacteria. Which prokaryotic …

Alternative splicing occurs in all eukaryotic organisms. Since the first description of
multiexon genes and the splicing machinery, the field has expanded rapidly, especially in …

Classification of introns, which is crucial to understanding their evolution and splicing, has
historically been binary and has resulted in the naming of major and minor introns that are …

Serine/arginine-rich (SR) proteins comprise a family of proteins that is predominantly found
in eukaryotes and plays a prominent role in RNA splicing. A characteristic feature of SR …

The emergence of introns was a significant evolutionary leap that is a major distinguishing
feature between prokaryotic and eukaryotic genomes. While historically introns were …