The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

The cerebral oxygen cascade includes three key stages:(a) convective oxygen delivery
representing the bulk flow of oxygen to the cerebral vascular bed;(b) diffusion of oxygen from …

Mitochondrial permeability transition pore (PTP), a (patho) physiological phenomenon
discovered over 40 years ago, is still not completely understood. PTP activation results in a …

Importance Experimental evidence suggests that cyclosporine prevents postcardiac arrest
syndrome by attenuating the systemic ischemia reperfusion response. Objective To …

Rationale: Intermittent hypoxia (IH) is one of the main features of sleep-disordered breathing
(SDB). Recent findings indicate that hypoxia inducible factor-1 (HIF-1) promotes …

Cyclosporine A (CsA), a classic immunosuppressant, is mainly applied for solid organ
transplantation and some autoimmune diseases by suppressing T lymphocytes. Early …

Aim of the study The aim of the study was to assess the prognostic impact of organ failures at
ICU admission after out-of-hospital cardiac arrest (CA) according to the SOFA score …

The opening of the mitochondrial permeability transition pore (PTP), which is regulated by
the matrix protein cyclophilin D (CypD), plays a key role in the pathophysiology of post …

Mitochondria is often considered as the common nexus of cardiac and cerebral dysfunction
after cardiac arrest. Here, our goal was to determine whether the time course of cardiac and …

Therapeutic hypothermia is neuroprotective after cardiac arrest (CA) via poorly understood
mechanisms. It may prevent mitochondrial permeability transition pore (PTP) opening, an …