The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer.
Interestingly, lactate closely links them together. However, lactate has long been recognized …

Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology of many
autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite …

Metabolic pathways must be adapted to support cell processes required for transformation
and cancer progression. Amino acid metabolism is deregulated in many cancers, with …

Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70%
of pancreatic ductal adenocarcinoma (PDAC),. Wild-type p53 accumulates in response to …