Man's best friend becomes biology's best in show: genome analyses in the domestic dog

HG Parker, AL Shearin… - Annual review of genetics, 2010 - annualreviews.org
In the last five years, canine genetics has gone from map construction to complex disease
deconstruction. The availability of a draft canine genome sequence, dense marker chips …

Genetic diversity, inbreeding and breeding practices in dogs: results from pedigree analyses

G Leroy - The Veterinary Journal, 2011 - Elsevier
Pedigree analysis constitutes a classical approach for the study of the evolution of genetic
diversity, genetic structure, history and breeding practices within a given breed. As a …

Large-scale diversification of skull shape in domestic dogs: disparity and modularity

AG Drake, CP Klingenberg - The american naturalist, 2010 - journals.uchicago.edu
The variation among domestic dog breeds offers a unique opportunity to study large-scale
diversification by microevolutionary mechanisms. We use geometric morphometrics to …

Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards

JF Summers, G Diesel, L Asher, PD McGreevy… - The Veterinary …, 2010 - Elsevier
Recent debate concerning health problems in pedigree animals has highlighted gaps in
current knowledge of the prevalence, severity and welfare implications of deleterious …

The challenges of pedigree dog health: approaches to combating inherited disease

LL Farrell, JJ Schoenebeck, P Wiener… - Canine genetics and …, 2015 - Springer
The issue of inherited disorders and poor health in pedigree dogs has been widely
discussed in recent years. With the advent of genome-wide sequencing technologies and …

The genomic architecture of segmental duplications and associated copy number variants in dogs

TJ Nicholas, Z Cheng, M Ventura, K Mealey… - Genome …, 2009 - genome.cshlp.org
Structural variation is an important and abundant source of genetic and phenotypic variation.
Here we describe the first systematic and genome-wide analysis of segmental duplications …

Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait map**

DL Dreger, M Rimbault, BW Davis… - Disease Models & …, 2016 - journals.biologists.com
In the decade following publication of the draft genome sequence of the domestic dog,
extraordinary advances with application to several fields have been credited to the canine …

Genetic diversity of dog breeds: within‐breed diversity comparing genealogical and molecular data

G Leroy, E Verrier, JC Meriaux, X Rognon - Animal Genetics, 2009 - Wiley Online Library
The genetic diversity of 61 dog breeds raised in France was investigated. Genealogical
analyses were performed on the pedigree file of the French kennel club. A total of 1514 dogs …

Origin and status of the Great Lakes wolf

S Koblmüller, M Nord, RK Wayne… - Molecular ecology, 2009 - Wiley Online Library
An extensive debate concerning the origin and taxonomic status of wolf‐like canids in the
North American Great Lakes region and the consequences for conservation politics …

Developmental validation of DogFiler, a novel multiplex for canine DNA profiling in forensic casework

E Wictum, T Kun, C Lindquist, J Malvick… - Forensic Science …, 2013 - Elsevier
While the analysis of human DNA has been the focus of large-scale collaborative
endeavors, non-human forensic DNA analysis has not benefited from the same funding …