Traumatic brain injury: progress and challenges in prevention, clinical care, and research
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for develo** new therapies for TBI. Current treatments for TBI are primarily focused …
crucial for develo** new therapies for TBI. Current treatments for TBI are primarily focused …
Brain oxygen optimization in severe traumatic brain injury phase-II: a phase II randomized trial
DO Okonkwo, LA Shutter, C Moore… - Critical care …, 2017 - journals.lww.com
Objectives: A relationship between reduced brain tissue oxygenation and poor outcome
following severe traumatic brain injury has been reported in observational studies. We …
following severe traumatic brain injury has been reported in observational studies. We …
Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders
GR Leitner, TJ Wenzel, N Marshall… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Adverse immune activation contributes to many central nervous system (CNS)
disorders. All main CNS cell types express toll-like receptor 4 (TLR 4). This receptor is …
disorders. All main CNS cell types express toll-like receptor 4 (TLR 4). This receptor is …
Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3): a multicentre, randomised, blinded-endpoint, comparative effectiveness study of brain tissue …
F Bernard, W Barsan, R Diaz-Arrastia, LH Merck… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Management of traumatic brain injury (TBI) includes invasive monitoring to
prevent secondary brain injuries. Intracranial pressure (ICP) monitor is the main …
prevent secondary brain injuries. Intracranial pressure (ICP) monitor is the main …
From ICU syndromes to ICU subphenotypes: consensus report and recommendations for develo** precision medicine in the ICU
Critical care uses syndromic definitions to describe patient groups for clinical practice and
research. There is growing recognition that a “precision medicine” approach is required and …
research. There is growing recognition that a “precision medicine” approach is required and …
A single-cell atlas deconstructs heterogeneity across multiple models in murine traumatic brain injury and identifies novel cell-specific targets
Traumatic brain injury (TBI) heterogeneity remains a critical barrier to translating therapies.
Identifying final common pathways/molecular signatures that integrate this heterogeneity …
Identifying final common pathways/molecular signatures that integrate this heterogeneity …
Zinc signal in brain diseases
The divalent cation zinc is an integral requirement for optimal cellular processes, whereby it
contributes to the function of over 300 enzymes, regulates intracellular signal transduction …
contributes to the function of over 300 enzymes, regulates intracellular signal transduction …
Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label …
Background Optimisation of brain oxygenation might improve neurological outcome after
traumatic brain injury. The OXY-TC trial explored the superiority of a strategy combining …
traumatic brain injury. The OXY-TC trial explored the superiority of a strategy combining …
Brain tissue oxygen monitoring in traumatic brain injury: part I—To what extent does PbtO2 reflect global cerebral physiology?
Background The primary aim was to explore the association of global cerebral physiological
variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral …
variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral …