Neurobiological basis of stress resilience

EJ Nestler, SJ Russo - Neuron, 2024 - cell.com
A majority of humans faced with severe stress maintain normal physiological and behavioral
function, a process referred to as resilience. Such stress resilience has been modeled in …

Precision medicine in complex diseases—Molecular subgrou** for improved prediction and treatment stratification

Å Johansson, OA Andreassen, S Brunak… - Journal of internal …, 2023 - Wiley Online Library
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …

Philosophy of psychiatry: theoretical advances and clinical implications

DJ Stein, K Nielsen, A Hartford… - World …, 2024 - Wiley Online Library
Work at the intersection of philosophy and psychiatry has an extensive and influential
history, and has received increased attention recently, with the emergence of professional …

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

M Tesfaye, P Jaholkowski, GFL Hindley, AA Shadrin… - Genome Medicine, 2023 - Springer
Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …

Did the human genome project affect research on schizophrenia?

EF Torrey - Psychiatry Research, 2024 - Elsevier
Abstract The Human Genome Project was undertaken primarily to discover genetic causes
and better treatments for human diseases. Schizophrenia was targeted since three of the …

Post‐traumatic stress disorder: evolving conceptualization and evidence, and future research directions

CR Brewin, L Atwoli, JI Bisson, S Galea… - World …, 2025 - Wiley Online Library
The understanding of responses to traumatic events has been greatly influenced by the
introduction of the diagnosis of post‐traumatic stress disorder (PTSD). In this paper we …

The genetic landscape of basal ganglia and implications for common brain disorders

S Bahrami, K Nordengen, J Rokicki, AA Shadrin… - Nature …, 2024 - nature.com
The basal ganglia are subcortical brain structures involved in motor control, cognition, and
emotion regulation. We conducted univariate and multivariate genome-wide association …

[HTML][HTML] How real-world data can facilitate the development of precision medicine treatment in psychiatry

E Koch, AF Pardiñas, KS O'Connell, P Selvaggi… - Biological …, 2024 - Elsevier
Precision medicine has the ambition to improve treatment response and clinical outcomes
through patient stratification and holds great potential for the treatment of mental disorders …

Sexual trauma, Polygenic Scores, and Mental Health diagnoses and outcomes

AM Lake, Y Zhou, B Wang, VA Ky'Era, Y Zhang… - JAMA …, 2025 - jamanetwork.com
Importance Leveraging real-world clinical biobanks to investigate the associations between
genetic and environmental risk factors for mental illness may help direct clinical screening …

Mental health and lower urinary tract symptoms: results from the NHANES and Mendelian randomization study

X Zhang, L Ma, J Li, W Zhang, Y **e, Y Wang - Journal of psychosomatic …, 2024 - Elsevier
Background The clinical observations suggest a correlation between lower urinary tract
symptoms (LUTSs) and mental health problems. Nonetheless, establishing a direct causal …