[HTML][HTML] Overcoming challenges in the delivery of STING agonists for cancer immunotherapy: a comprehensive review of strategies and future perspectives
C Huang, N Shao, Y Huang, J Chen, D Wang, G Hu… - Materials Today Bio, 2023 - Elsevier
Abstract STING (Stimulator of Interferon Genes) agonists have emerged as promising agents
in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate …
in the field of cancer immunotherapy, owing to their excellent capacity to activate the innate …
Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles
Intravenously administered cyclic dinucleotides and other STING agonists are hampered by
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …
cGAS‐STING pathway agonists are promising vaccine adjuvants
X Tian, J Ai, X Tian, X Wei - Medicinal Research Reviews, 2024 - Wiley Online Library
Adjuvants are of critical value in vaccine development as they act on enhancing
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …
Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy
Integrating multimodal neuro-and nanotechnology-enabled precision immunotherapies with
extant systemic immunotherapies may finally provide a significant breakthrough for …
extant systemic immunotherapies may finally provide a significant breakthrough for …
Localized nanoparticle‐mediated delivery of miR‐29b normalizes the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting …
Patients diagnosed with osteosarcoma undergo extensive surgical intervention and
chemotherapy resulting in dismal prognosis and compromised quality of life owing to poor …
chemotherapy resulting in dismal prognosis and compromised quality of life owing to poor …
Spherical nucleic acid vaccine structure markedly influences adaptive immune responses of clinically utilized prostate cancer targets
Cancer vaccines, which activate the immune system against a target antigen, are attractive
for prostate cancer, where multiple upregulated protein targets are identified. However …
for prostate cancer, where multiple upregulated protein targets are identified. However …
Matrix Metalloproteinase-and pH-Sensitive Nanoparticle System Enhances Drug Retention and Penetration in Glioblastoma
Glioblastoma (GBM) is a primary malignant brain tumor with limited therapeutic options. One
promising approach is local drug delivery, but the efficacy is hindered by limited diffusion …
promising approach is local drug delivery, but the efficacy is hindered by limited diffusion …
Harnessing cGAS‐STING pathway for cancer immunotherapy: from Bench to clinic
Recent advances in cancer immunotherapy have accomplished clinical successes in certain
cancer models over the past decade. However, cancer treatments with adoptive cell transfer …
cancer models over the past decade. However, cancer treatments with adoptive cell transfer …
Nomadic Nanomedicines: Medicines Enabled by the Paracrine Transfer Effect
In nanomedicine, the cellular export of nanomaterials has been less explored than uptake.
Traditionally viewed in a negative light, recent findings highlight the potential of …
Traditionally viewed in a negative light, recent findings highlight the potential of …
Overcoming STING agonists barriers: peptide, protein, and biomembrane‐based biocompatible delivery strategies
YF Zheng, JJ Wu - Chemistry–An Asian Journal, 2022 - Wiley Online Library
After development for more than ten years, stimulator of interferon genes (STING), a
representative of pattern recognition receptors (PRRs), is now entering the stage of …
representative of pattern recognition receptors (PRRs), is now entering the stage of …