In the recent years, the vast amount of genetic information generated by new-generation
approaches, have led to the need of new data handling methods. The integrative analysis of …

One of the main challenges for healthcare systems is the increasing prevalence of
neurodegenerative pathologies together with the rapidly aging populations. The enormous …

Abstract Motivation Gene regulatory networks (GRNs) are a way of describing the interaction
between genes, which contribute to revealing the different biological mechanisms in the cell …

The EGFR tyrosine kinase inhibitor gefitinib is commonly used for lung cancer patients.
However, some patients eventually become resistant to gefitinib and develop progressive …

The large-scale advancement of high-throughput sequencing technologies has enabled the
interrogation of different regulatory layers. Especially the development of computational …

Reconstructing a gene regulatory network from one or more sets of omics measurements
has been a major task of computational biology in the last 20 years. Despite an …

Gene regulation is one of the most important cellular processes and closely interlinked
pathogenesis. The elucidation of regulatory mechanisms can be approached by many …

This Ph. D. thesis aims to describe all the research works conducted for the design,
development and evaluation of intelligent frameworks for supporting the diagnosis in several …