Gangliosides are sialic acid-containing glycosphingolipids that are most abundant in the
nervous system. They are localized primarily in the outer leaflets of plasma membranes and …

Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases
with age. Although two of the main pathological features of AD, amyloid plaques and …

Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are
mostly found as terminal residues in glycan structures of glycoconjugates including both …

It is widely accepted that the abnormal self-association of amyloid β-protein (Aβ) is central to
the pathogenesis of Alzheimer's disease, the most common form of dementia. Accumulating …

Autophagy, the major lysosomal pathway for the turnover of intracellular organelles is
markedly impaired in neurons in Alzheimer's disease and Alzheimer mouse models. We …

The major pathological hallmarks of Alzheimer's disease (AD) are the progressive
aggregation and accumulation of beta-amyloid (Aβ) and hyperphosphorylated tau protein …

Sphingolipids (SLs) play a significant role in the nervous system, as major components of
the myelin sheath, contributors to lipid raft formation that organize intracellular processes, as …

Age-related alterations of membrane lipids in brain cell membranes together with high blood
cholesterol are considered as major risk factors for Alzheimer's disease. Yet the molecular …

Background Understanding of the significance of posttranslational glycosylation in
Alzheimer's disease (AD) is of growing importance for the investigation of the pathogenesis …

Abstract Background Alzheimer's Disease (AD) affects millions globally, but therapy
development is lagging. New experimental systems that monitor neuronal functions in …