Apoptosis, also named programmed cell death, is a fundament process required for
morphogenetic homeostasis during early development and in pathophysiological …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …

The use of potent therapies inhibiting critical oncogenic pathways active in epithelial
cancers has led to multiple resistance mechanisms, including the development of highly …

Background Immunohistochemistry (IHC) is a well-established, widely accepted method in
both clinical and experimental parts of medical science. It allows receiving valuable …

The immense majority of genes are alternatively spliced and there are many isoforms
specifically associated with cancer progression and metastasis. The splicing pattern of …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

BCL-2 was the first anti-death gene discovered, a milestone with far reaching implications
for tumor biology. Multiple members of the human Bcl-2 family of apoptosis-regulating …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

Background Survivin is expressed in prostate cancer (PCa), and its downregulation
sensitizes PCa cells to chemotherapeutic agents in vitro and in vivo. Small membrane …