Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
X Chen, C Shi, M He, S **ong, X **a - Signal transduction and targeted …, 2023 - nature.com
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …
[HTML][HTML] A guide to understanding endoplasmic reticulum stress in metabolic disorders
Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …
cardiovascular disease, demands a thorough molecular understanding of the cellular …
Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
Lipid droplet functions beyond energy storage
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …
for energy metabolism. Their function in energy storage is firmly established and …
Endoplasmic reticulum stress and autophagy
Z Qi, L Chen - Autophagy: Biology and diseases: Basic science, 2019 - Springer
In 1945, KR Porter et al. observed mouse embryonic fibroblasts (MEFs) and found that the
cytoplasmic part of the cell had an unreported reticular structure, so it was named …
cytoplasmic part of the cell had an unreported reticular structure, so it was named …
A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes
Lipid droplet (LD) functions are regulated by a complement of integral and peripheral
proteins that associate with the bounding LD phospholipid monolayer. Defining the …
proteins that associate with the bounding LD phospholipid monolayer. Defining the …
Glycosylation-directed quality control of protein folding
C Xu, DTW Ng - Nature reviews Molecular cell biology, 2015 - nature.com
Membrane-bound and soluble proteins of the secretory pathway are commonly glycosylated
in the endoplasmic reticulum. These adducts have many biological functions, including …
in the endoplasmic reticulum. These adducts have many biological functions, including …
Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …
membranes and associated proteins are linked to the thermodynamics and kinetics of …
[HTML][HTML] Cytoplasmic vacuolization in cell death and survival
Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known
morphological phenomenon observed in mammalian cells after exposure to bacterial or viral …
morphological phenomenon observed in mammalian cells after exposure to bacterial or viral …
[HTML][HTML] Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system
I Amm, T Sommer, DH Wolf - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Mistakes are part of our world and constantly occurring. Due to transcriptional and
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …