Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

One of the recently emerging topics in biotechnology is natural receptors including G protein-
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and
secretory proteins, which, collectively, represent a large fraction of the total protein output of …

Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …

Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the
forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic …

The recognition of odorants by olfactory receptors represents the first stage in odor
discrimination. Here, we report the generation of an expression library containing a large …

To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

Rhodopsin, the visual pigment mediating vision under dim light, is composed of the
apoprotein opsin and the chromophore ligand 11-cis-retinal. A P23H mutation in the opsin …

We inserted into the germline of mice either a mutant or wild-type allele from a patient with
retinitis pigmentosa and a missense mutation (P23H) in the rhodop sin gene. All three lines …