Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …

Mechanisms of Thrombus Formation | New England Journal of Medicine Skip to main content
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Expanding evidence indicates multiple interactions between the hemostatic system and
innate immunity, and the coagulation and complement cascades. Here we show in a tissue …

Platelets interact with the coagulation system in a multitude of ways, not only during the
phases of thrombus formation, but also in specific areas within a formed thrombus. This …

Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity
and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein …

Considerable interest for cell-derived microparticles has emerged, pointing out their
essential role in haemostatic response and their potential as disease markers, but also their …

Thiol isomerases, including protein disulfide isomerase (PDI), catalyze disulfide oxidation,
reduction, and isomerization, thereby playing an important role in protein synthesis. To …

The available data suggest that among cellular constituents, proteins are the major target for
oxidation primarily because of their quantity and high rate of interactions with ROS. Proteins …

Summary Background: Tissue factor (TF)‐bearing microparticles (MP) from different origins
are thought to be involved in the pathogenesis of cancer‐associated thrombosis. However …

Tissue factor (TF) is an integral membrane protein, normally separated from the blood by the
vascular endothelium, which plays a key role in the initiation of blood coagulation. With a …