Male infertility
A Agarwal, S Baskaran, N Parekh, CL Cho, R Henkel… - The Lancet, 2021 - thelancet.com
It is estimated that infertility affects 8–12% of couples globally, with a male factor being a
primary or contributing cause in approximately 50% of couples. Causes of male subfertility …
primary or contributing cause in approximately 50% of couples. Causes of male subfertility …
Semen proteomics and male infertility
Semen is a complex body fluid containing an admixture of spermatozoa suspended in
secretions from the testes and epididymis which are mixed at the time of ejaculation with …
secretions from the testes and epididymis which are mixed at the time of ejaculation with …
The exosome: a review of current therapeutic roles and capabilities in human reproduction
Abstract Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic
delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the …
delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the …
Role of oxidative stress in varicocele
K Wang, Y Gao, C Wang, M Liang, Y Liao… - Frontiers in Genetics, 2022 - frontiersin.org
According to the official statistics of the World Health Organization, at least 48 million
couples and 186 million people suffer from infertility. Varicocele has been recognized as the …
couples and 186 million people suffer from infertility. Varicocele has been recognized as the …
[HTML][HTML] From pathophysiology to practice: addressing oxidative stress and sperm DNA fragmentation in Varicocele-affected subfertile men
Varicocele can reduce male fertility potential through various oxidative stress mechanisms.
Excessive production of reactive oxygen species may overwhelm the sperm's defenses …
Excessive production of reactive oxygen species may overwhelm the sperm's defenses …
Proteomics and metabolomics—Current and future perspectives in clinical andrology
MK Panner Selvam, R Finelli, A Agarwal… - Andrologia, 2021 - Wiley Online Library
Proteomics and metabolomics are emerging as promising tools to investigate the molecular
mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in …
mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in …
Proteomic analyses of human sperm cells: understanding the role of proteins and molecular pathways affecting male reproductive health
A Agarwal, MK Panner Selvam, S Baskaran - International Journal of …, 2020 - mdpi.com
Human sperm proteomics research has gained increasing attention lately, which provides
complete information about the functional state of the spermatozoa. Changes in the sperm …
complete information about the functional state of the spermatozoa. Changes in the sperm …
The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility
L Gómez-H, N Felipe-Medina, YB Condezo… - PLoS …, 2019 - journals.plos.org
The ubiquitin proteasome system regulates meiotic recombination in yeast through its
association with the synaptonemal complex, a 'zipper'-like structure that holds homologous …
association with the synaptonemal complex, a 'zipper'-like structure that holds homologous …
Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility
To study the major differences in the distribution of spermatozoa proteins in infertile men
with varicocele by comparative proteomics and validation of their level of expression. The …
with varicocele by comparative proteomics and validation of their level of expression. The …
Post-Translational Modifications in sperm Proteome: The Chemistry of Proteome diversifications in the Pathophysiology of male factor infertility
Background The spermatozoa undergo a series of changes in the epididymis to mature after
their release from the testis and subsequently in the female reproductive tract after …
their release from the testis and subsequently in the female reproductive tract after …