Developmental mechanisms underlying the evolution of human cortical circuits
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
[HTML][HTML] Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain?
Highlights•Adult human synapses show long-term potentiation and depression.•Activity-
dependent rules for associative plasticity have broad temporal windows.•Synaptic plasticity …
dependent rules for associative plasticity have broad temporal windows.•Synaptic plasticity …
Connectomic comparison of mouse and human cortex
The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …
of a mouse, but the possible differences in synaptic circuits between these species are still …
Conserved cell types with divergent features in human versus mouse cortex
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …
Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type
We describe convergent evidence from transcriptomics, morphology, and physiology for a
specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus …
specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus …
Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex
Synaptic transmission constitutes the primary mode of communication between neurons. It is
extensively studied in rodent but not human neocortex. We characterized synaptic …
extensively studied in rodent but not human neocortex. We characterized synaptic …
Advancing preclinical models of psychiatric disorders with human brain organoid cultures
TA Dixon, AR Muotri - Molecular Psychiatry, 2023 - nature.com
Psychiatric disorders are often distinguished from neurological disorders in that the former
do not have characteristic lesions or findings from cerebrospinal fluid …
do not have characteristic lesions or findings from cerebrospinal fluid …
Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy
Focal cortical dysplasia type I (FCD I) is the most common cause of pharmaco-resistant
epilepsy with the poorest prognosis. To understand the epileptogenic mechanisms of FCD I …
epilepsy with the poorest prognosis. To understand the epileptogenic mechanisms of FCD I …
CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny
N Assendorp, M Fossati, B Libé-Philippot… - Cell Reports, 2024 - cell.com
Human-specific genes are potential drivers of brain evolution. Among them, SRGAP2C has
contributed to the emergence of features characterizing human cortical synapses, including …
contributed to the emergence of features characterizing human cortical synapses, including …
HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex
Accumulating evidence indicates that there are substantial species differences in the
properties of mammalian neurons, yet theories on circuit activity and information processing …
properties of mammalian neurons, yet theories on circuit activity and information processing …