How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …
Developmental and functional heterogeneity of monocytes
Novel experimental approaches such as fate-map** and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …
fresh insight into monocyte development and function over the past decade and helped …
Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
Macrophage polarization and metabolism in atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …
Nonclassical monocytes in health and disease
PB Narasimhan, P Marcovecchio… - Annual review of …, 2019 - annualreviews.org
Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of …
responders to pathogens in acute infections. There are three well-characterized classes of …
Monocytes, macrophages, and their potential niches in synovial joints–therapeutic targets in post-traumatic osteoarthritis?
Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …
undergo a series of changes, including a prevalent inflammatory response. This increases …
Myeloid cell contributions to cardiovascular health and disease
M Nahrendorf - Nature medicine, 2018 - nature.com
Recent advances in cell tracing and sequencing technologies have expanded our
knowledge on leukocyte behavior. As a consequence, inflammatory cells, such as monocyte …
knowledge on leukocyte behavior. As a consequence, inflammatory cells, such as monocyte …
Inflammatory cells in atherosclerosis
Atherosclerosis is a chronic progressive disease that involves damage to the intima,
inflammatory cell recruitment and the accumulation of lipids followed by calcification and …
inflammatory cell recruitment and the accumulation of lipids followed by calcification and …
Monocyte regulation in homeostasis and malignancy
Monocytes are progenitors to macrophages and a subclass of dendritic cells (monocyte-
derived dendritic cells, MoDCs), but they also act as circulating sensors that respond to …
derived dendritic cells, MoDCs), but they also act as circulating sensors that respond to …