Lack of behavioral suppression typifies substance use disorders, yet the neural circuit
underpinnings of drug-induced behavioral disinhibition remain unclear. Here, we employ …

Chronic pain, as a social public health problem, has a serious impact on the quality of
patients' life. Currently, the main drugs used to treat chronic pain are opioids, antipyretic, and …

Chronic opioid exposure induces tolerance to the pain-relieving effects of opioids but
sensitization to some other effects. While the occurrence of these adaptations is well …

Painful stimuli elicit first-line reflexive defensive reactions and, in many cases, also evoke
second-line recuperative behaviors, the latter of which reflects the sensing of tissue damage …

Introduction The paraventricular thalamic nucleus (PVT) is recognized for its critical role in
pain regulation, yet the precise molecular mechanisms involved remain poorly understood …

The paraventricular thalamic nucleus (PVT) is a brain region that mediates aversive and
reward-related behaviors as shown in animals exposed to fear conditioning, natural …

Aberrant signaling within cortical inhibitory microcircuits has been identified as a common
signature of neuropsychiatric disorders. Interneuron (IN) activity is precisely regulated by …

This paper is the forty-sixth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Opioids are regarded as the most effective therapy for pain. However, their clinical use is
limited by their dangerous side effects, high abuse liability, and the rapid development of …