An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

Stem cell regulation and hierarchical organization of human skeletal progenitors remain
largely unexplored. Here, we report the isolation of a self-renewing and multipotent human …

Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …

Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been
extensively investigated for their therapeutic potential in treating inflammatory disorders …

DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …

The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

Mesenchymal stromal cells (MSCs) are currently being investigated for use in a wide variety
of clinical applications. For most of these applications, systemic delivery of the cells is …

The essential physiological role of platelets in wound healing and tissue repair builds the
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …

A widely shared view reads that mesenchymal stem/stromal cells (" MSCs") are ubiquitous in
human connective tissues, can be defined by a common in vitro phenotype, share a …