CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
Elucidating the interactome of G protein-coupled receptors and receptor activity-modifying proteins
G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …
integral membrane proteins that modulate their biology and pharmacology. However, the …
A structural basis for amylin receptor phenotype
Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of
three receptor activity–modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R. Selective …
three receptor activity–modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R. Selective …
Development of cagrilintide, a long-acting amylin analogue
T Kruse, JL Hansen, K Dahl, L Schaffer… - Journal of Medicinal …, 2021 - ACS Publications
A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of
amyloid fibrils, which makes it a challenging drug design effort. The amylin analogue …
amyloid fibrils, which makes it a challenging drug design effort. The amylin analogue …
Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene‐related peptide responsive receptors
ML Garelja, TI Alexander, A Bennie… - British journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Calcitonin gene‐related peptide (CGRP) is involved in
migraine pathophysiology. CGRP can signal through two receptors. The canonical CGRP …
migraine pathophysiology. CGRP can signal through two receptors. The canonical CGRP …
CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists?
The development of several drugs that target the calcitonin gene‐related peptide (CGRP)
system has been a major breakthrough in the pharmacological management of migraine …
system has been a major breakthrough in the pharmacological management of migraine …
β-Cell death in diabetes: past discoveries, present understanding, and potential future advances
β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia
in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and …
in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and …
Diabetes and its Complications
S Matoori - ACS Pharmacology & Translational Science, 2022 - ACS Publications
Diabetes mellitus is defined as “a group of metabolic diseases characterized by
hyperglycemia [increased blood glucose levels] resulting from defects in insulin secretion …
hyperglycemia [increased blood glucose levels] resulting from defects in insulin secretion …