Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

Recent technological advances have expanded the breadth of available omic data, from
whole-genome sequencing data, to extensive transcriptomic, methylomic and metabolomic …

Purpose Breast cancer (BC) risk prediction allows systematic identification of individuals at
highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence …

Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor
subtype,–. To identify novel loci, we performed a genome-wide association study including …

METTL3 is an RNA methyltransferase implicated in mRNA biogenesis, decay, and
translation control through N 6-methyladenosine (m 6 A) modification. Here we find that …

Linkage and candidate gene studies have identified several breast cancer susceptibility
genes, but the overall contribution of coding variation to breast cancer is unclear. To …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Most common breast cancer susceptibility variants have been identified through genome-
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …

Background: Data for multiple common susceptibility alleles for breast cancer may be
combined to identify women at different levels of breast cancer risk. Such stratification could …

Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …