Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …

Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …

Simple Summary Small cell lung cancer (SCLC) accounts for about 15% of lung cancers
and it has limited therapeutic options and poor prognosis. There has been no real progress …

Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes,
macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases …

Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine via its
ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only …

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been
characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain B …

For the past decade, the role and importance of neutrophils in cancer is being increasingly
appreciated. Research has focused on the ability of cancer-related neutrophils to either …

The opposing roles of innate and adaptive immune cells in suppressing or supporting
cancer initiation, progression, metastasis and response to therapy has been long debated …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that
suppress T-cell activity in a tumor microenvironment. However, the suppressive function of …

A major mechanism through which neutrophils have been suggested to modulate tumor
progression involves the interaction and subsequent modulation of other infiltrating immune …