Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples

H Liu, Y Pan, C **ong, J Han, X Wang, J Chen… - TrAC Trends in Analytical …, 2022 - Elsevier
Endogenous small molecules play important roles in biological processes and are closely
related to the occurrence and development of many diseases. Profiling of spatial distribution …

Material-assisted mass spectrometric analysis of low molecular weight compounds for biomedical applications

AS Kulkarni, L Huang, K Qian - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Low molecular weight compounds play an important role in encoding the current
physiological state of an individual. Laser desorption/ionization mass spectrometry (LDI MS) …

Organic metal chalcogenide-assisted metabolic molecular diagnosis of central precocious puberty

D Ouyang, C Wang, C Zhong, J Lin, G Xu, G Wang… - Chemical …, 2024 - pubs.rsc.org
Metabolic analysis in biofluids based on laser desorption/ionization mass spectrometry (LDI-
MS), featuring rapidity, simplicity, small sample volume and high throughput, is expected to …

Design of Multi‐Shelled Hollow Cr2O3 Spheres for Metabolic Fingerprinting

R Li, Y Zhou, C Liu, C Pei, W Shu… - Angewandte Chemie …, 2021 - Wiley Online Library
Schizophrenia (SZ) detection enables effective treatment to improve the clinical outcome,
but objective and reliable SZ diagnostics are still limited. An ideal diagnosis of SZ suited for …

Nanometer resolution mass spectro-microtomography for In-depth anatomical profiling of single cells

HZ Mou, J Pan, CL Zhao, L **ng, Y Mo, B Kang… - ACS …, 2023 - ACS Publications
Visually identifying the molecular changes in single cells is of great importance for
unraveling fundamental cellular functions as well as disease mechanisms. Herein, we …

MALDI matrices for the analysis of low molecular weight compounds: rational design, challenges and perspectives

Z Qiao, F Lissel - Chemistry–An Asian Journal, 2021 - Wiley Online Library
The analysis of low molecular weight (LMW) compounds is of great interest to detect small
pharmaceutical drugs rapidly and sensitively, or to trace and understand metabolic …

When a picture is worth a thousand words: Molecular and elemental imaging applied to environmental analysis–A review

DS Francischini, MAZ Arruda - Microchemical Journal, 2021 - Elsevier
As spectral imaging is gaining special attention in the last years, once it allows transforming
the chemical information from a sample surface into a high-resolution image of elemental …

On-Tissue Chemical Derivatization of Catecholamines Using 4-(N-Methyl)pyridinium Boronic Acid for ToF-SIMS and LDI-ToF Mass Spectrometry Imaging

I Kaya, SM Brülls, J Dunevall, E Jennische… - Analytical …, 2018 - ACS Publications
The analysis of small polar compounds with ToF-SIMS and MALDI-ToF-MS have been
generally hindered by low detection sensitivity, poor ionization efficiency, ion suppression …

Novel magnetic single-layer nano-MXene as a highly effective adsorbent and new SALDI-TOF-MS matrix for enrichment and rapid determination of p …

Z Peng, W Zhang, D Yin, X Zhang, S Liu, W Zhao… - Chemical Engineering …, 2023 - Elsevier
A novel magnetic single-layer nano-MXene (SNM@ Fe 3 O 4) was prepared for the first time
with small size, high surface area, abundant active sites and excellent energy …

Extracting Structural Data from MALDI-ToF Mass Spectrometry Analysis of Alternating Conjugated Polymers–A Case Study on PBTTT Derivatives

J Vanderspikken, P Verstappen, W Maes - Macromolecules, 2024 - ACS Publications
The incorporation of organic molecules has transformed the (mobile phone) displays market,
yet the widespread use of conjugated polymers in optoelectronic applications remains …