Aliphatic three-and four-membered rings including cyclopropanes, cyclobutanes, oxetanes,
azetidines and bicyclo [1.1. 1] pentanes have been increasingly exploited in medicinal …

Conspectus It has been over half a century since the last class of antibiotics active against
the most problematic Gram-negative bacteria was approved by the Food and Drug …

Genomic studies and experiments with permeability-deficient strains have revealed a variety
of biological targets that can be engaged to kill Gram-negative bacteria. However, the …

Gram-negative bacterial infections are a significant public health concern, and the lack of
new drug classes for these pathogens is linked to the inability of most drug leads to …

This chapter provides an overview of literature from 1996 on the applications of various
furan and benzofuran containing compounds. In addition to compounds that contain a furan …

A one-pot microwave assisted telescopic approach is reported for the chemo-selective
synthesis of substituted 1, 3-thiazetidines using readily available 2-aminopyridines …

Methicillin-resistant Staphylococcus aureus (MRSA) is a threat to global health.
Consequently, much effort has focused on the development of new antimicrobials that target …

A new N, N′-disubstituted piperazine conjugated with 1, 3, 4-thiadiazole and 1, 2, 4-triazole
was prepared and the chemical structures were identified by IR, NMR and elemental …

This review provides a comprehensive survey of proprietary drug discovery and
development efforts performed by Indian companies between 1994 and mid‐2016. It is …

Antimicrobials targeting the fatty acid synthesis (FASII) pathway are being developed as
alternative treatments for bacterial infections. Emergence of resistance to FASII inhibitors …