The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

INTRODUCTION Various methods of super-resolution (SR) fluorescence microscopy have
the potential to follow the dynamic nanoscale interactions of specific macromolecular …

Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at
the cell cortex or in association with other cytoskeletal proteins, such as actin or …

Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

Tissue flow during morphogenesis is commonly driven by local constriction of cell cortices,
which is caused by the activation of actomyosin contractility. This can lead to long-range …

Cells change shape in response to diverse environmental and developmental conditions,
creating topologies with micron-scale features. Although individual proteins can sense …

Many aspects of cytoskeletal assembly and dynamics can be recapitulated in vitro; yet, how
the cytoskeleton integrates signals in vivo across cellular membranes is far less understood …

Essential cellular functions as diverse as genome maintenance and tissue morphogenesis
rely on the dynamic organization of filamentous assemblies. For example, the precise …