As a response to environmental changes driven by the Earth's axial rotation, most organisms
evolved an internal biological timer—the so called circadian clock—which regulates …

Apoptosis is the best described form of regulated cell death, and was, until relatively
recently, considered irreversible once particular biochemical points-of-no-return were …

Stochastic restart may drastically reduce the expected run time of a computer algorithm,
expedite the completion of a complex search process, or increase the turnover rate of an …

The stochasticity of gene expression presents significant challenges to the modeling of
genetic networks. A two-state model describing promoter switching, transcription, and …

Mammalian cells have two fundamentally different states, proliferative and quiescent, but our
understanding of how and why cells switch between these states is limited. We previously …

Although molecular mechanisms that prompt cell-cycle arrest in response to DNA damage
have been elucidated, the systems-level properties of DNA damage checkpoints are not …

Methods to rapidly assess cell growth would be useful for many applications, including drug
susceptibility testing, but current technologies have limited sensitivity or throughput. Here we …

Bacteria employ diverse motility patterns in traversing complex three-dimensional (3D)
natural habitats. 2D microscopy misses crucial features of 3D behaviour, but the applicability …

Single-cell methods are beginning to reveal the intrinsic heterogeneity in cell populations,
arising from the interplay of deterministic and stochastic processes. However, it remains …

We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-
generational lineage tracking under controlled culture conditions. We use this platform to …