The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

The renin-angiotensin system is a central component of the physiological and pathological
responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

AT1R (angiotensin type 1 receptor) and AT2R (angiotensin type 2 receptor) are well known
to be involved in the complex cardiovascular actions of AngII (angiotensin II). However …

Over the past decade, extensive research has focused on identifying the molecular
mechanisms and signal transduction pathways involved in the modulation of vascular …

838 medication have significant differences with regard to their ancillary pharmacological
properties and thereby also their profile at a molecular/cellular level. Furthermore, these …

The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …

Hypertension is one of the cardiovascular diseases that might cause cardiovascular
remodeling and endothelial dysfunction besides high blood pressure. Angiotensin II (Ang II) …