Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …

Chromatin regulatory landscape plays a critical role in many disease processes and embryo
development. Epigenome sequencing technologies such as chromatin immunoprecipitation …

Background T cells generated from thymopoiesis are essential for the immune system, and
recent single-cell studies have contributed to our understanding of the development of …

Epigenetics studies inheritable and reversible modifications of DNA that allow cells to
control gene expression throughout their development and in response to environmental …

Although mitotic chromosomes are highly compacted and transcriptionally inert, some active
chromatin features are retained during mitosis to ensure the proper postmitotic …

Genome-wide profiling of chromatin accessibility by DNase-seq or ATAC-seq has been
widely used to identify regulatory DNA elements and transcription factor binding sites …

The tremendous progress of single-cell sequencing technology has given researchers the
opportunity to study cell development and differentiation processes at single-cell resolution …

Single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) identifies
regulated chromatin accessibility modules at the single-cell resolution. Robust evaluation is …

Emerging single-cell epigenomic assays are used to investigate the heterogeneity of
chromatin activity and its function. However, identifying cells with distinct regulatory …

Assays for transposase-accessible chromatin through high-throughput sequencing (ATAC-
seq) are effective tools in the study of genome-wide chromatin accessibility landscapes. With …