p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …

Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …

As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Abstract PAKs, p21-activated kinases, play central roles and act as converging junctions for
discrete signals elicited on the cell surface and for a number of intracellular signaling …

Abstract The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family,
was initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a …

Different types of cell behavior, including growth, motility, and navigation, require actin
proteins to assemble into filaments. Here, we describe a biochemical process that was able …

Paks (p21‐activated kinases) are effectors for the small GTPases Cdc42 (cell division cycle
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …

Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments.
They are found on a variety of cell types and have been ascribed sensory or exploratory …

Rho GTPases are small proteins that act as binary molecular switches in a wide range of
signalling pathways upon stimulation of cell surface receptors. Three different classes of …

The p21-activated kinase (PAK) family of serine/threonine kinases is important in
physiological processes including motility, survival, mitosis, transcription and translation …