Current targets and bioconjugation strategies in photodynamic diagnosis and therapy of cancer

S Gomez, A Tsung, Z Hu - Molecules, 2020 - mdpi.com
Photodynamic diagnosis (PDD) and therapy (PDT) are emerging, non/minimally invasive
techniques for cancer diagnosis and treatment. Both techniques require a photosensitizer …

[HTML][HTML] Advances in the genetically engineered KillerRed for photodynamic therapy applications

J Liu, F Wang, Y Qin, X Feng - International journal of molecular sciences, 2021 - mdpi.com
Photodynamic therapy (PDT) is a clinical treatment for cancer or non-neoplastic diseases,
and the photosensitizers (PSs) are crucial for PDT efficiency. The commonly used chemical …

Upconversion in photodynamic therapy: Plumbing the depths

MR Hamblin - Dalton Transactions, 2018 - pubs.rsc.org
Photodynamic therapy (PDT) involves the combination of non-toxic dyes called
photosensitizers (PS) and harmless visible light that interact with ambient oxygen to give …

Rational design of bioavailable photosensitizers for manipulation and imaging of biological systems

TC Binns, AX Ayala, JB Grimm, AN Tkachuk… - Cell chemical …, 2020 - cell.com
Light-mediated chemical reactions are powerful methods for manipulating and interrogating
biological systems. Photosensitizers, compounds that generate reactive oxygen species …

Recent Advances in Bio‐Compatible Oxygen Singlet Generation and Its Tumor Treatment

ZY **, H Fatima, Y Zhang, Z Shao… - Advanced …, 2022 - Wiley Online Library
Light‐dependent singlet oxygen (1O2) produced in photodynamic therapy (PDT), is a
biologically compatible reactive oxygen species showing the potential to kill tumor cells with …

Interaction of genetically encoded photosensitizers with scintillating nanoparticles for X-ray activated photodynamic therapy

MC Micheletto, EJ Guidelli… - ACS Applied Materials & …, 2021 - ACS Publications
Photodynamic therapy (PDT) applications are limited by the low penetration of UV–visible
light into biological tissues. Considering X-rays as an alternative to excite photosensitizers …

Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation

M Petrenčáková, F Filandr, A Hovan, G Yassaghi… - Scientific reports, 2020 - nature.com
Flavin mononucleotide (FMN) belongs to the group of very efficient endogenous
photosensitizers producing singlet oxygen, 1O2, but with limited ability to be targeted. On the …

Enhancement of the efficacy of photodynamic therapy against uropathogenic gram-negative bacteria species

V Elagin, I Budruev, A Antonyan, P Bureev, N Ignatova… - Photonics, 2023 - mdpi.com
Antimicrobial photodynamic therapy (aPDT) was demonstrated to be effective against
various species of Gram-positive bacteria. However, the complex structure of a Gram …

Photodynamic physiology—Photonanomanipulations in cellular physiology with protein photosensitizers

HN Jiang, Y Li, ZJ Cui - Frontiers in Physiology, 2017 - frontiersin.org
Singlet oxygen generated in a type II photodynamic action, due to its limited lifetime (1 μs)
and reactive distance (< 10 nm), could regulate live cell function nanoscopically. The …

Cardiac optogenetics: a novel approach to cardiovascular disease therapy

C Jiang, HT Li, YM Zhou, X Wang, L Wang… - Ep …, 2018 - academic.oup.com
Optogenetics is a cell-type specific and high spatial–temporal resolution method that
combines genetic encoding of light-sensitive proteins and optical manipulation techniques …