Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast
cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed …

Required by an increasing amount of scientists, the in silico docking field is in full expansion,
new algorithms and methods appearing at an exponential rate. The sheer range of available …

Aromatase is an enzyme that plays a critical role in the development of estrogen receptor
positive breast cancer. As aromatase catalyzes the aromatization of androstenedione to …

Bacterial resistance is responsible for a wide variety of health problems, both in children and
adults. The persistence of symptoms and infections are mainly treated with β-lactam …

Protein tyrosine phosphatase 1B (PTP1B) plays a vital role in the regulation of insulin
sensitivity and dephosphorylation of the insulin receptor, so PTP1B inhibitors may be …

Since nimesulide, a nonsteroidal anti-inflammatory drug, is known to be a selective inhibitor
of cyclooxygenase-2 and shows activity against cancer cells, there has been much interest …

In this contribution, the role of epistemology in understanding quantum chemistry is
discussed. Quantum chemistry is the study of the behavior of atoms and molecules using the …

Carboxylesterases (CEs) are important enzymes that catalyze biological detoxification,
hydrolysis of certain pesticides, and metabolism of many esterified drugs. The development …

The super-saturation of serum with monosodium urate due to hyperuricemia is the core
metabolic disorder of rheumatoid arthritis. When the serum urate concentration is≥ 7 mg/dl …

Our previous studies showed that L-tyrosine derivatives possessed potential inhibitory
activities against matrix metalloproteinase-2 (MMP-2), a target greatly embodied in tumor …