There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of
microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer …

Dihydropyrimidine dehydrogenase (DPYD) is the rate-limiting enzyme involved in the
metabolism of fluoropyrimidine-based chemotherapy. However, single-nucleotide variants …

Aim: MicroRNA 27a (miR-27a) regulates post-transcriptionally DPD activity. We have
analyzed the association of MIR27A rs895819T> C variation, that modulates miR-27a …

Background: Helicobacter pylori (Hp) persistent infection is an important pathogenic factor
for a series of chronic gastric diseases from chronic gastritis to gastric cancer. Genetic and …

The cancers of the gastrointestinal (GI) tract have become a common diagnosis worldwide
contributing to a large number of mortalities. Though potentially curable they are mostly fatal …

Background: While different studies have investigated the association of SNPs with female
reproductive disorders, a limited number of studies have investigated the effect of …

Various studies have shown that selective molecular recognition of RNA targets by small
molecules in cells, although challenging, is indeed possible. One facile strategy to enhance …

Background: MiR27a plays an important role in carcinogenesis, cell proliferation, apoptosis,
invasion, migration and angiogenesis. Several studies have identified an important role of …

Background Cancer of the digestive system is a common cancer and results in high mortality
rates world-wide. miR-27a polymorphism has been associated with an increased risk of …

Multiple microRNAs (miRs) are associated with systemic autoimmune disease susceptibility/
phenotype, including systemic lupus erythematosus (SLE). With this work, we aimed to …