Applications, challenges, and needs for employing synthetic biology beyond the lab

SM Brooks, HS Alper - Nature Communications, 2021 - nature.com
Synthetic biology holds great promise for addressing global needs. However, most current
developments are not immediately translatable to 'outside-the-lab'scenarios that differ from …

DNA as a universal chemical substrate for computing and data storage

S Yang, BWA Bögels, F Wang, C Xu, H Dou… - Nature Reviews …, 2024 - nature.com
DNA computing and DNA data storage are emerging fields that are unlocking new
possibilities in information technology and diagnostics. These approaches use DNA …

Bimetallic single-atom nanozyme-based electrochemical-photothermal dual-function portable immunoassay with smartphone imaging

Y Wang, R Zeng, S Tian, S Chen, Z Bi, D Tang… - Analytical …, 2024 - ACS Publications
Rapid and accurate detection of human epidermal growth factor receptor 2 (HER2) is crucial
for the early diagnosis and prognosis of breast cancer. In this study, we reported an iron …

CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

M Karlikow, E Amalfitano, X Yang, J Doucet… - Nature …, 2023 - nature.com
Nucleic acid sensing powered by the sequence recognition of CRIPSR technologies has
enabled major advancement toward rapid, accurate and deployable diagnostics. While …

Emerging biosensing and transducing techniques for potential applications in point-of-care diagnostics

J Qin, W Wang, L Gao, SQ Yao - Chemical Science, 2022 - pubs.rsc.org
With the deepening of our understanding in life science, molecular biology, nanotechnology,
optics, electrochemistry and other areas, an increasing number of biosensor design …

Cascade strand displacement and bipedal walking based DNA logic system for miRNA diagnostics

P Miao, Y Tang - ACS central science, 2021 - ACS Publications
DNA logic gated operations empower the highly efficient analysis of multiplex nucleic acid
inputs, which have attracted extensive attention. However, the integration of DNA logic gates …

Electrochemical cell‐free biosensors for antibody detection

S Bracaglia, S Ranallo, F Ricci - Angewandte Chemie, 2023 - Wiley Online Library
We report here the development of an electrochemical cell‐free biosensor for antibody
detection directly in complex sample matrices with high sensitivity and specificity that is …

Bioelectronic control of a microbial community using surface-assembled electrogenetic cells to route signals

JL Terrell, T Tschirhart, JP Jahnke, K Stephens… - Nature …, 2021 - nature.com
We developed a bioelectronic communication system that is enabled by a redox signal
transduction modality to exchange information between a living cell-embedded …

Recent advancements in bipolar electrochemical methods of analysis

KL Rahn, RK Anand - Analytical Chemistry, 2020 - ACS Publications
The goal of this review is to provide an overview of the advancements made in the field of
bipolar electrochemistry over the past 2 years, with an emphasis on analysis. Bipolar …

A glucose meter interface for point-of-care gene circuit-based diagnostics

E Amalfitano, M Karlikow, M Norouzi, K Jaenes… - Nature …, 2021 - nature.com
Recent advances in cell-free synthetic biology have given rise to gene circuit-based sensors
with the potential to provide decentralized and low-cost molecular diagnostics. However, it …