Human embryogenesis is hallmarked by two phases of yolk sac development. The primate
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Understanding lineage specification during human pre-implantation development is a
gateway to improving assisted reproductive technologies and stem cell research. Here we …

Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …

The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo
remains controversial. We present transcriptional and functional data to identify the …

The mouse embryo is the canonical model for mammalian preimplantation development.
Recent advances in single cell profiling allow detailed analysis of embryogenesis in other …

Early mammalian embryogenesis is controlled by mechanisms governing the balance
between pluripotency and differentiation. The expression of early lineage-specific genes can …

It is now recognized that extensive expression heterogeneities among cells precede the
emergence of lineages in the early mammalian embryo. To establish a map of pluripotent …

During blastocyst formation, inner cell mass (ICM) cells differentiate into either epiblast (Epi)
or primitive endoderm (PrE) cells, labeled by Nanog and Gata6, respectively, and organized …

Activation of the FGF signaling pathway during preimplantation development of the mouse
embryo is known to be essential for differentiation of the inner cell mass and the formation of …