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Nonalcoholic fatty liver disease and cardiovascular risk: a scientific statement from the American Heart Association
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is
believed to affect> 25% of adults worldwide. Unless specific testing is done to identify …
believed to affect> 25% of adults worldwide. Unless specific testing is done to identify …
2019 Global NAFLD prevalence: a systematic review and meta-analysis
Background & Aims The increasing rates of obesity and type 2 diabetes mellitus may lead to
increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine …
increased prevalence of nonalcoholic fatty liver disease (NAFLD). We aimed to determine …
GLP-1 receptor agonists in non-alcoholic fatty liver disease: current evidence and future perspectives
To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease,
affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available …
affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available …
A randomized, controlled trial of the pan-PPAR agonist lanifibranor in NASH
Background Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need.
Lanifibranor is a pan-PPAR (peroxisome proliferator–activated receptor) agonist that …
Lanifibranor is a pan-PPAR (peroxisome proliferator–activated receptor) agonist that …
Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020
Nonalcoholic fatty liver disease (NAFLD) has become a serious public health issue not only
in Western countries but also in Japan. Within the wide spectrum of NAFLD, nonalcoholic …
in Western countries but also in Japan. Within the wide spectrum of NAFLD, nonalcoholic …
Immunology of human fibrosis
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
Metabolic inflammation and insulin resistance in obesity
Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …
[HTML][HTML] Liver fibrosis: mechanistic concepts and therapeutic perspectives
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …
Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities
Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis
KC Lee, PS Wu, HC Lin - Clinical and molecular hepatology, 2022 - pmc.ncbi.nlm.nih.gov
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …