Nanomedicine tumor targeting

T Lammers - Advanced Materials, 2024 - Wiley Online Library
Nanomedicines are extensively explored for cancer therapy. By delivering drug molecules
more efficiently to pathological sites and by attenuating their accumulation in healthy organs …

Designing drug delivery systems for cell therapy

LLW Wang, Y Gao, Z Feng, DJ Mooney… - Nature Reviews …, 2024 - nature.com
Cell therapies, such as immune cell and stem cell therapies, are being preclinically and
clinically explored for the treatment of various diseases, but are often limited by low efficacy …

Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy

N Kumbhojkar, S Prakash, T Fukuta… - Nature Biomedical …, 2024 - nature.com
Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-
tumoural phenotype in the immunosuppressive tumour microenvironment. Here we show …

Polymer micropatches as natural killer cell engagers for tumor therapy

S Prakash, N Kumbhojkar, A Lu, N Kapate, VC Suja… - ACS …, 2023 - ACS Publications
Natural killer (NK) cell therapies have emerged as a potential therapeutic approach to
various cancers. Their efficacy, however, is limited by their low persistence and anergy …

[HTML][HTML] ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair

R Hua, C Zhao, Z Xu, D Liu, W Shen, W Yuan, Y Li… - Bioactive Materials, 2024 - Elsevier
Spinal cord injury (SCI) is a traumatic condition that results in impaired motor and sensory
function. Ferroptosis is one of the main causes of neural cell death and loss of neurological …

Cell-mediated nanoparticle delivery systems: towards precision nanomedicine

R Cheng, S Wang - Drug Delivery and Translational Research, 2024 - Springer
Cell-mediated nanoparticle delivery systems (CMNDDs) utilize cells as carriers to deliver the
drug-loaded nanoparticles. Unlike the traditional nanoparticle drug delivery approaches …

Emerging strategies for nanomedicine in autoimmunity

AS Thatte, MM Billingsley, D Weissman… - Advanced Drug Delivery …, 2024 - Elsevier
Autoimmune disorders have risen to be among the most prevalent chronic diseases across
the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily …

Polymer backpack‐loaded tissue infiltrating monocytes for treating cancer

N Kapate, M Dunne, AP Gottlieb… - Advanced …, 2024 - Wiley Online Library
Adoptive cell therapies are dramatically altering the treatment landscape of cancer.
However, treatment of solid tumors remains a major unmet need, in part due to limited …

[HTML][HTML] Current knowledge about nonclassical monocytes in patients with multiple sclerosis, a systematic review

B Arneth - International Journal of Molecular Sciences, 2024 - mdpi.com
Monocytes play a critical role in the initiation and progression of multiple sclerosis (MS).
Recent research indicates the importance of considering the roles of monocytes in the …

The plasticity of immune cell response complicates dissecting the underlying pathology of multiple sclerosis

SK Sarkar, AML Willson… - Journal of Immunology …, 2024 - Wiley Online Library
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease characterized by the
destruction of the myelin sheath of the neuronal axon in the central nervous system. Many …