Apical–basal polarity and the control of epithelial form and function
CE Buckley, D St Johnston - Nature reviews Molecular cell biology, 2022 - nature.com
Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
Tumour–host interactions through the lens of Drosophila
There is a large gap between the deep understanding of mechanisms driving tumour growth
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …
Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS
Y Adachi, R Kimura, K Hirade, S Yanase, Y Nishioka… - Nature Cancer, 2023 - nature.com
Tumor cells evade targeted drugs by rewiring their genetic and epigenetic networks. Here,
we identified that inhibition of MAPK signaling rapidly induces an epithelial-to-mesenchymal …
we identified that inhibition of MAPK signaling rapidly induces an epithelial-to-mesenchymal …
[HTML][HTML] P120 and E-cadherin: Double-edged swords in tumor metastasis
JH Venhuizen, FJC Jacobs, PN Span… - Seminars in cancer …, 2020 - Elsevier
Cell-cell adhesion by adherens junctions controls proliferation and cell polarization and is
crucial to maintain epithelial architecture and homeostasis. Downregulation of two of the …
crucial to maintain epithelial architecture and homeostasis. Downregulation of two of the …
Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5
The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and
outside the nucleus. However, it is currently unclear whether and how the distribution of …
outside the nucleus. However, it is currently unclear whether and how the distribution of …
[HTML][HTML] Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics
Tight and adherens junctions are specialized sites of cell-cell interaction in epithelia and
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …
Epithelial monitoring through ligand-receptor segregation ensures malignant cell elimination
G de Vreede, SU Gerlach, D Bilder - Science, 2022 - science.org
Animals have evolved mechanisms, such as cell competition, to remove dangerous or
nonfunctional cells from a tissue. Tumor necrosis factor signaling can eliminate clonal …
nonfunctional cells from a tissue. Tumor necrosis factor signaling can eliminate clonal …
[HTML][HTML] New insights into apical-basal polarization in epithelia
The establishment of an apical–basal axis of polarity is essential for the organization and
functioning of epithelial cells. Polarization of epithelial cells is orchestrated by a network of …
functioning of epithelial cells. Polarization of epithelial cells is orchestrated by a network of …
New insights into the organization and regulation of the apical polarity network in mammalian epithelial cells
Cell polarity is a fundamental property of most animal cells and is critical during
development and for most cell and tissue functions. Epithelial cells are organized into apical …
development and for most cell and tissue functions. Epithelial cells are organized into apical …
The Scribble family in cancer: twentieth anniversary
Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic
scaffold Scribble stands out because of its essential role in many steps of cancer …
scaffold Scribble stands out because of its essential role in many steps of cancer …