Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …

Develo** reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

An increasingly popular method of assessing cognitive functions in rodents is the automated
touchscreen platform, on which a number of different cognitive tests can be run in a manner …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Cognitive deficits in schizophrenia remain an unmet clinical need. Improved understanding
of the neuro-and psychopathology of these deficits depends on the availability of carefully …

We describe a touchscreen method that satisfies a proposed 'wish-list'of desirables for a
cognitive testing method for assessing rodent models of schizophrenia. A number of tests …

Growing evidence supports a major contribution of cortical serotonin (5-hydroxytryptamine, 5-
HT) to the modulation of cognitive flexibility and the cognitive inflexibility evident in …

Schizophrenia is a complex developmental disorder that presents challenges to modern
neuroscience in terms of discovering etiology and aiding in effective treatment of afflicted …

Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not
adequately responding to treatment. Phencyclidine (PCP) is used as a validated model for …

Schizophrenia patients suffer from cognitive impairments that are not satisfactorily treated by
currently available medications. Cognitive dysfunction in schizophrenia encompasses …