New clinical trial design in precision medicine: discovery, development and direction

XP Duan, BD Qin, XD Jiao, K Liu, Z Wang… - Signal Transduction and …, 2024 - nature.com
In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine

I Dakilah, A Harb, E Abu-Gharbieh… - Frontiers in …, 2024 - frontiersin.org
The global burden of cancer continues to rise, underscoring the urgency of develo** more
effective and precisely targeted therapies. This comprehensive review explores the …

Digital twins as global learning health and disease models for preventive and personalized medicine

X Li, J Loscalzo, AKMF Mahmud, DM Aly, A Rzhetsky… - Genome Medicine, 2025 - Springer
Ineffective medication is a major healthcare problem causing significant patient suffering
and economic costs. This issue stems from the complex nature of diseases, which involve …

Role of liposomes in chemoimmunotherapy of Breast cancer

F Attarian, G Hatamian, S Nosrati… - Journal of Drug …, 2025 - Taylor & Francis
In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous
promise, especially for aggressive forms of breast cancer like triple-negative breast cancer …

Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and …

L Chang, J Liu, J Zhu, S Guo, Y Wang… - Cancer Biology & …, 2025 - cancerbiomed.org
Artificial intelligence (AI) is significantly advancing precision medicine, particularly in the
fields of immunogenomics, radiomics, and pathomics. In immunogenomics, AI can process …

[HTML][HTML] Synergistic Effects of Mistletoe Lectin and Cisplatin on Triple-Negative Breast Cancer Cells: Insights from 2D and 3D In Vitro Models

SY Lyu, SM Meshesha, CE Hong - International Journal of Molecular …, 2025 - mdpi.com
Triple-negative breast cancer (TNBC) remains a challenging subtype due to its aggressive
nature and limited treatment options. This study investigated the potential synergistic effects …

Analysis of the Effects of Bevacizumab Combined with Chemoradiotherapy on VEGF, bFGF, and Let-7 Levels in Non-Small Cell Lung Cancer and the Factors …

XC Luo, P Tang, PX Zhong - International Journal of General …, 2024 - Taylor & Francis
Objective To explore the influence of bevacizumab combined with chemoradiotherapy on
VEGF, bFGF, and Let-7 in patients with non-small cell lung cancer (NSCLC), and to analyze …

Drug Repositioning Using Single-Cell RNA Sequencing in Cancer Research

MR Abdullah-Zawawi, SN Chan, FYF Tieng… - 2024 - Springer
Single-cell RNA sequencing (scRNA-seq) is a valuable tool for investigating cellular
dynamics at the transcriptome level, enabling researchers to delve into the interactions of …

The Interplay between p53 and the Tumor Microenvironment in Progressing Breast Cancer

S Handa, M Chatterjee, N Jan, MA Mir - p53 in Breast Cancer, 2025 - taylorfrancis.com
Breast cancer represents a multifaceted oncological challenge characterized by
dysregulated cellular proliferation within mammary tissue and is a significant global health …

[PDF][PDF] Digital Twins as Global Learning Health and Disease Models of Individuals

X Li, J Loscalzo, AKMF Mahmud, DMA Aly, A Rzhetsky… - 2024 - preprints.org
Emerging molecular and computational techniques may allow construction and
computational treatment of dynamic digital twins on the scale of populations to individuals …