Background Inappropriate polypharmacy is a particular concern in older people and is
associated with negative health outcomes. Choosing the best interventions to improve …

Background Mixed findings about deprescribing impact have emerged from varied study
designs, interventions, outcome measures and targeting sub-categories of medications or …

OBJECTIVES Older people approaching end of life are commonly prescribed multiple
medications, many of which may be inappropriate or futile. Our objective was to examine the …

Introduction: There is increasing recognition of the need for deprescribing of inappropriate
medications in older adults. However, efforts to encourage implementation of deprescribing …

Objectives Deprescribing reduces polypharmacy in older adults. A thorough study of the
effect of deprescribing interventions on clinical outcomes in older adults is presently lacking …

Interpreting results from deprescribing interventions to generate actionable evidence is
challenging owing to inconsistent and heterogeneous outcome definitions between studies …

Introduction Anticholinergic medications block the neurotransmitter acetylcholine in the brain
and peripheral nervous system. Many medications have anticholinergic properties, and the …

Objective To evaluate if a pharmacist-led medication review is effective at reducing the
anticholinergic/sedative load, as measured by the Drug Burden Index (DBI). Design …

Recent medical advancements have increased life expectancy, leading to a surge in
patients affected by multiple chronic diseases and consequent polypharmacy, especially …

Objectives Approximately 98% of older Americans are simultaneously taking 5—or more—
medications to manage at least 2 chronic conditions. Polypharmacy and the use of …