Organoids

Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

[HTML][HTML] AI-enabled organoids: construction, analysis, and application

L Bai, Y Wu, G Li, W Zhang, H Zhang, J Su - Bioactive materials, 2024 - Elsevier
Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …

Revealing the clinical potential of high-resolution organoids

J Ko, S Hyung, S Cheong, Y Chung, NL Jeon - Advanced Drug Delivery …, 2024 - Elsevier
The symbiotic interplay of organoid technology and advanced imaging strategies yields
innovative breakthroughs in research and clinical applications. Organoids, intricate three …

AI‐organoid integrated systems for biomedical studies and applications

S Maramraju, A Kowalczewski, A Kaza… - Bioengineering & …, 2024 - Wiley Online Library
In this review, we explore the growing role of artificial intelligence (AI) in advancing the
biomedical applications of human pluripotent stem cell (hPSC)‐derived organoids. Stem cell …

[HTML][HTML] Harnessing the power of artificial intelligence for human living organoid research

H Wang, X Li, X You, G Zhao - Bioactive Materials, 2024 - Elsevier
As a powerful paradigm, artificial intelligence (AI) is rapidly impacting every aspect of our
day-to-day life and scientific research through interdisciplinary transformations. Living …

Morphological profiling for drug discovery in the era of deep learning

Q Tang, R Ratnayake, G Seabra, Z Jiang… - Briefings in …, 2024 - academic.oup.com
Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-
throughput automated imaging has enabled the capturing of a wide range of morphological …

Advancing cancer research through organoid technology

G Zeng, Y Yu, M Wang, J Liu, G He, S Yu, H Yan… - Journal of Translational …, 2024 - Springer
The complexity of tumors and the challenges associated with treatment often stem from the
limitations of existing models in accurately replicating authentic tumors. Recently, organoid …

3D cell cultures toward quantitative high-throughput drug screening

Y Wang, H Jeon - Trends in Pharmacological Sciences, 2022 - cell.com
3D cell cultures are being utilized for drug discovery and development. However, there are
still challenges to implementing them generally in quantitative high-throughput screening …

Balance between the Cell Viability and Death in 3D

AC Debruyne, IA Okkelman, RI Dmitriev - Seminars in Cell & …, 2023 - Elsevier
Cell death is a phenomenon, frequently perceived as an absolute event for cell, tissue and
the organ. However, the rising popularity and complexity of such 3D multicellular 'tissue …

Challenges and advances in optical 3D mesoscale imaging

S Munck, C Cawthorne, A Escamilla‐Ayala… - Journal of …, 2022 - Wiley Online Library
Optical mesoscale imaging is a rapidly develo** field that allows the visualisation of larger
samples than is possible with standard light microscopy, and fills a gap between cell and …