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Effects of creatine supplementation on brain function and health
While the vast majority of research involving creatine supplementation has focused on
skeletal muscle, there is a small body of accumulating research that has focused on creatine …
skeletal muscle, there is a small body of accumulating research that has focused on creatine …
ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?
D Petrov, C Mansfield, A Moussy… - Frontiers in aging …, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of
30,000 patients a year worldwide. The median reported survival time since onset ranges …
30,000 patients a year worldwide. The median reported survival time since onset ranges …
“Heads up” for creatine supplementation and its potential applications for brain health and function
There is emerging interest regarding the potential beneficial effects of creatine
supplementation on indices of brain health and function. Creatine supplementation can …
supplementation on indices of brain health and function. Creatine supplementation can …
Energy metabolism in ALS: an underappreciated opportunity?
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …
Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?
H Mitsumoto, BR Brooks, V Silani - The Lancet Neurology, 2014 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is one of the most rapidly progressive
neurodegenerative diseases of unknown cause. Riluzole is the only drug that slows disease …
neurodegenerative diseases of unknown cause. Riluzole is the only drug that slows disease …
Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
Amyotrophic lateral sclerosis and environmental factors
V Bozzoni, O Pansarasa, L Diamanti… - Functional …, 2016 - pmc.ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects central
and peripheral motor neuron cells. Its etiology is unknown, although a relationship between …
and peripheral motor neuron cells. Its etiology is unknown, although a relationship between …
Drug discovery and amyotrophic lateral sclerosis: emerging challenges and therapeutic opportunities
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …
Synthesis and transport of creatine in the CNS: importance for cerebral functions
E Béard, O Braissant - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 115, 297–313. Abstract Apart of its well known function of 'energetic
buffer'through the creatine/phosphocreatine/creatine kinase system allowing the …
buffer'through the creatine/phosphocreatine/creatine kinase system allowing the …
Evidence of metabolic dysfunction in amyotrophic lateral sclerosis (ALS) patients and animal models
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor
neurons, leading to muscle weakness, paralysis, and eventual death. Research from the …
neurons, leading to muscle weakness, paralysis, and eventual death. Research from the …