Effects of creatine supplementation on brain function and health

SC Forbes, DM Cordingley, SM Cornish, B Gualano… - Nutrients, 2022 - mdpi.com
While the vast majority of research involving creatine supplementation has focused on
skeletal muscle, there is a small body of accumulating research that has focused on creatine …

ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?

D Petrov, C Mansfield, A Moussy… - Frontiers in aging …, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of
30,000 patients a year worldwide. The median reported survival time since onset ranges …

“Heads up” for creatine supplementation and its potential applications for brain health and function

DG Candow, SC Forbes, SM Ostojic, K Prokopidis… - Sports Medicine, 2023 - Springer
There is emerging interest regarding the potential beneficial effects of creatine
supplementation on indices of brain health and function. Creatine supplementation can …

Energy metabolism in ALS: an underappreciated opportunity?

T Vandoorne, K De Bock, L Van Den Bosch - Acta neuropathologica, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …

Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

H Mitsumoto, BR Brooks, V Silani - The Lancet Neurology, 2014 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is one of the most rapidly progressive
neurodegenerative diseases of unknown cause. Riluzole is the only drug that slows disease …

Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis

B Sever, H Ciftci, H DeMirci, H Sever, F Ocak… - International journal of …, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …

Amyotrophic lateral sclerosis and environmental factors

V Bozzoni, O Pansarasa, L Diamanti… - Functional …, 2016 - pmc.ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that affects central
and peripheral motor neuron cells. Its etiology is unknown, although a relationship between …

Drug discovery and amyotrophic lateral sclerosis: emerging challenges and therapeutic opportunities

P Soares, C Silva, D Chavarria, FSG Silva… - Ageing research …, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

Synthesis and transport of creatine in the CNS: importance for cerebral functions

E Béard, O Braissant - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 115, 297–313. Abstract Apart of its well known function of 'energetic
buffer'through the creatine/phosphocreatine/creatine kinase system allowing the …

Evidence of metabolic dysfunction in amyotrophic lateral sclerosis (ALS) patients and animal models

K Maksimovic, M Youssef, J You, HK Sung, J Park - Biomolecules, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor
neurons, leading to muscle weakness, paralysis, and eventual death. Research from the …