Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

Cell surface glycosylation is dynamic and often changes in response to cellular
differentiation under physiological or pathophysiological conditions. Altered glycosylation on …

Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the
onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2 …

Since the early discovery of plant lectins at the end of the 19th century, and the finding that
they could agglutinate erythrocytes and precipitate glycans from their solutions, many …

Cisplatin-based chemotherapeutic regimens are the most frequently used (neo) adjuvant
treatments for the majority of solid tumors. While platinum-based chemotherapeutic …

Glycosylation is a common post-translational modification process of proteins. Mucin-type O-
glycosylation is an O-glycosylation that starts from protein serine/threonine residues …

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the
malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose …

Bladder cancer is the most common malignancy of the urinary tract, presents the highest
recurrence rate among solid tumors and is the second leading cause of death in …

Cancer remains a leading cause of death worldwide due to the lack of safer and more
effective therapies. Cancer vaccines developed from neoantigens are an emerging strategy …