AI in the clinical management of GA: a novel therapeutic universe requires novel tools

GS Reiter, J Mai, S Riedl, K Birner, S Frank… - Progress in Retinal and …, 2024 - Elsevier
Regulatory approval of the first two therapeutic substances for the management of
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a major …

[HTML][HTML] Artificial intelligence for geographic atrophy: pearls and pitfalls

ML Enzendorfer, U Schmidt-Erfurth - Current Opinion in …, 2024 - journals.lww.com
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Oral antioxidant and lutein/zeaxanthin supplements slow geographic atrophy progression to the fovea in age-related macular degeneration

TDL Keenan, E Agrón, PA Keane, A Domalpally… - Ophthalmology, 2025 - Elsevier
Purpose To determine whether oral micronutrient supplementation slows geographic
atrophy (GA) progression in age-related macular degeneration (AMD). Design Post hoc …

[HTML][HTML] Geographic atrophy segmentation using multimodal deep learning

T Spaide, J Jiang, J Patil, N Anegondi… - … Vision Science & …, 2023 - iovs.arvojournals.org
Purpose: To examine deep learning (DL)–based methods for accurate segmentation of
geographic atrophy (GA) lesions using fundus autofluorescence (FAF) and near-infrared …

Ophthalmology Optical Coherence Tomography Databases for Artificial Intelligence Algorithm: A Review

D Restrepo, JM Quion… - Seminars in …, 2024 - Taylor & Francis
Background Imaging plays a pivotal role in eye assessment. With the introduction of
advanced machine learning and artificial intelligence (AI), the focus has shifted to imaging …

Using Ensemble OCT-Derived Features beyond Intensity Features for Enhanced Stargardt Atrophy Prediction with Deep Learning

Z Mishra, Z Wang, SVR Sadda, Z Hu - Applied Sciences, 2023 - mdpi.com
Featured Application This study shows promising results for the development of artificial
intelligence tools for the predicting of the progression of Stargardt disease. It further offers …

Combination of optical coherence tomography-derived shape and texture features are associated with development of sub-foveal geographic atrophy in dry AMD

SS Kar, H Cetin, J Abraham, SK Srivastava… - Scientific Reports, 2024 - nature.com
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration
(AMD) that leads to progressive and irreversible vision loss. Identifying patients with greatest …

Artificial intelligence in assessing progression of age-related macular degeneration

S Frank-Publig, K Birner, S Riedl, GS Reiter… - Eye, 2024 - nature.com
The human population is steadily growing with increased life expectancy, impacting the
prevalence of age-dependent diseases, including age-related macular degeneration (AMD) …

“Super‐covariates”: Using predicted control group outcome as a covariate in randomized clinical trials

B Holzhauer, ET Adewuyi - Pharmaceutical Statistics, 2023 - Wiley Online Library
The power of randomized controlled clinical trials to demonstrate the efficacy of a drug
compared with a control group depends not just on how efficacious the drug is, but also on …

Identifying geographic atrophy

L Clevenger, A Rachitskaya - Current Opinion in Ophthalmology, 2023 - journals.lww.com
Identification of GA and of risk factors for GA development or progression is essential when
counseling AMD patients and discussing prognosis. With new therapies on the horizon for …