Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium
CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics
across a wide range of organisms, including the Plasmodium parasites that cause malaria …
across a wide range of organisms, including the Plasmodium parasites that cause malaria …
[HTML][HTML] Therapeutic and diagnostic relevance of Crispr technology
A Djekoun - Biomedicine & Pharmacotherapy, 2021 - Elsevier
CRISPR is a family of DNA repeats providing immunity against viral and plasmid invading
DNA in bacteria and archaea. The system consist of an endonuclease Cas, guided by a …
DNA in bacteria and archaea. The system consist of an endonuclease Cas, guided by a …
Improvement of CRISPR/Cas9 system by transfecting Cas9-expressing Plasmodium berghei with linear donor template
Malaria is caused by infection with Plasmodium parasites and is a major public health
concern. The CRISPR/Cas9 system is a promising technology, but still has technical …
concern. The CRISPR/Cas9 system is a promising technology, but still has technical …
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
B Franke-Fayard, C Marin-Mogollon, FJA Geurten… - npj Vaccines, 2022 - nature.com
Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal
malaria models and in humans. A recent clinical trial with a WSp vaccine comprising …
malaria models and in humans. A recent clinical trial with a WSp vaccine comprising …
Highly efficient CRISPR/Cas9 system in Plasmodium falciparum using Cas9-expressing parasites and a linear donor template
The CRISPR/Cas9 system is a powerful genetic engineering technology for Plasmodium
falciparum. We here report further improvement of the CRISPR/Cas9 system by combining …
falciparum. We here report further improvement of the CRISPR/Cas9 system by combining …
Genetic manipulation toolkits in Apicomplexan parasites
Z Niu, L Xue, X Yin, B Shen - Zoonoses, 2022 - scienceopen.com
Apicomplexan parasites are a group of intracellular pathogens of great medical and
veterinary importance, including Toxoplasma gondii and Plasmodium, which cause …
veterinary importance, including Toxoplasma gondii and Plasmodium, which cause …