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IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
Intracerebral hemorrhage (ICH) is a devastating form of stroke affecting millions of people
worldwide. Parenchymal hematoma triggers a series of reactions leading to primary and …
worldwide. Parenchymal hematoma triggers a series of reactions leading to primary and …
A perspective on roles played by innate and adaptive immunity in the pathobiology of neurodegenerative disorders
Aberrant innate and adaptive immune responses are neurodegenerative disease effectors.
Disease is heralded by a generalized, but subtle immune activation orchestrated by the …
Disease is heralded by a generalized, but subtle immune activation orchestrated by the …
CD8 T-cell recruitment into the central nervous system of cuprizone-fed mice: relevance to modeling the etiology of multiple sclerosis
Cuprizone (CPZ)-feeding in mice induces atrophy of peripheral immune organs (thymus and
spleen) and suppresses T-cell levels, thereby limiting its use as a model for studying the …
spleen) and suppresses T-cell levels, thereby limiting its use as a model for studying the …
Omega‐3 fatty acids decrease prostate cancer progression associated with an anti‐tumor immune response in eugonadal and castrated mice
Background Several lines of evidence suggest effects of dietary fat on prostate cancer (PCa)
development and progression. Targeting omega (ω)‐3: ω6 fatty acids (FA) ratio could be …
development and progression. Targeting omega (ω)‐3: ω6 fatty acids (FA) ratio could be …
Androgen receptor transcriptionally regulates μ-opioid receptor expression in rat trigeminal ganglia
The involvement of testosterone in pain, inflammation, and analgesia has been reported, but
the role of androgen receptor (AR), a steroid receptor for testosterone, is not well …
the role of androgen receptor (AR), a steroid receptor for testosterone, is not well …
Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis
VM McLeod, CL Lau, MDF Chiam… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative
disease typically more common in males, implicating androgens in progression of both …
disease typically more common in males, implicating androgens in progression of both …
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice
Defects in the RNA-binding proteins survival motor neuron (SMN) and TAR DNA-binding
protein 43 (TDP-43) cause progressive motor neuron degeneration in spinal muscular …
protein 43 (TDP-43) cause progressive motor neuron degeneration in spinal muscular …
Dysregulation of steroid hormone receptors in motor neurons and glia associates with disease progression in ALS mice
VM McLeod, MDF Chiam, CL Lau… - …, 2020 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting motor neurons
which shows sexual dimorphism in its incidence, age of onset, and progression rate. All …
which shows sexual dimorphism in its incidence, age of onset, and progression rate. All …
Alteration of Golgi structure by stress: a link to neurodegeneration?
The Golgi apparatus is well-known for its role as a sorting station in the secretory pathway as
well as for its role in regulating post-translational protein modification. Another role for the …
well as for its role in regulating post-translational protein modification. Another role for the …
Compulsive‐like eating of high‐fat high‐sugar food is associated with 'addiction‐like'glutamatergic dysfunction in obesity prone rats
Chronic overeating is a core feature of diet‐induced obesity. There is increasing evidence
that in vulnerable individuals, such overeating could become compulsive, resembling an …
that in vulnerable individuals, such overeating could become compulsive, resembling an …