IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

J Xu, Z Chen, F Yu, H Liu, C Ma, D **e, X Hu… - Proceedings of the …, 2020 - pnas.org
Intracerebral hemorrhage (ICH) is a devastating form of stroke affecting millions of people
worldwide. Parenchymal hematoma triggers a series of reactions leading to primary and …

A perspective on roles played by innate and adaptive immunity in the pathobiology of neurodegenerative disorders

HE Gendelman, RL Mosley - Journal of Neuroimmune Pharmacology, 2015 - Springer
Aberrant innate and adaptive immune responses are neurodegenerative disease effectors.
Disease is heralded by a generalized, but subtle immune activation orchestrated by the …

CD8 T-cell recruitment into the central nervous system of cuprizone-fed mice: relevance to modeling the etiology of multiple sclerosis

MSM Almuslehi, MK Sen, PJ Shortland… - Frontiers in Cellular …, 2020 - frontiersin.org
Cuprizone (CPZ)-feeding in mice induces atrophy of peripheral immune organs (thymus and
spleen) and suppresses T-cell levels, thereby limiting its use as a model for studying the …

Omega‐3 fatty acids decrease prostate cancer progression associated with an anti‐tumor immune response in eugonadal and castrated mice

N Gevariya, M Besançon, K Robitaille, V Picard… - The …, 2019 - Wiley Online Library
Background Several lines of evidence suggest effects of dietary fat on prostate cancer (PCa)
development and progression. Targeting omega (ω)‐3: ω6 fatty acids (FA) ratio could be …

Androgen receptor transcriptionally regulates μ-opioid receptor expression in rat trigeminal ganglia

KS Lee, Y Zhang, J Asgar, QS Auh, MK Chung, JY Ro - Neuroscience, 2016 - Elsevier
The involvement of testosterone in pain, inflammation, and analgesia has been reported, but
the role of androgen receptor (AR), a steroid receptor for testosterone, is not well …

Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

VM McLeod, CL Lau, MDF Chiam… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative
disease typically more common in males, implicating androgens in progression of both …

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

ND Perera, RK Sheean, PJ Crouch… - Human molecular …, 2016 - academic.oup.com
Defects in the RNA-binding proteins survival motor neuron (SMN) and TAR DNA-binding
protein 43 (TDP-43) cause progressive motor neuron degeneration in spinal muscular …

Dysregulation of steroid hormone receptors in motor neurons and glia associates with disease progression in ALS mice

VM McLeod, MDF Chiam, CL Lau… - …, 2020 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease targeting motor neurons
which shows sexual dimorphism in its incidence, age of onset, and progression rate. All …

Alteration of Golgi structure by stress: a link to neurodegeneration?

EA Alvarez-Miranda, M Sinnl, H Farhan - Frontiers in neuroscience, 2015 - frontiersin.org
The Golgi apparatus is well-known for its role as a sorting station in the secretory pathway as
well as for its role in regulating post-translational protein modification. Another role for the …

Compulsive‐like eating of high‐fat high‐sugar food is associated with 'addiction‐like'glutamatergic dysfunction in obesity prone rats

D Sketriene, D Battista, L Lalert… - Addiction …, 2022 - Wiley Online Library
Chronic overeating is a core feature of diet‐induced obesity. There is increasing evidence
that in vulnerable individuals, such overeating could become compulsive, resembling an …